Paper: Sep 14,2024
q-bio.GN
ID:2409.09314
The Future of Decoding Non-Standard Nucleotides: Leveraging Nanopore Sequencing for Expanded Genetic Codes
Expanding genetic codes from natural standard nucleotides to artificial
non-standard nucleotides marks a significant advancement in synthetic biology,
with profound implications for biotechnology and medicine. Decoding the
biological information encoded in these non-standard nucleotides presents new
challenges, as traditional sequencing technologies are unable to recognize or
interpret novel base pairings. In this perspective, we explore the potential of
nanopore sequencing, which is uniquely suited to decipher both standard and
non-standard nucleotides by directly measuring the biophysical properties of
nucleic acids. Nanopore technology offers real-time, long-read sequencing
without the need for amplification or synthesis, making it particularly
advantageous for expanded genetic systems like Artificially Expanded Genetic
Information Systems (AEGIS). We discuss how the adaptability of nanopore
sequencing and advancements in data processing can unlock the potential of
these synthetic genomes and open new frontiers in understanding and utilizing
expanded genetic codes.
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Paper Author: Hyunjin Shim
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