Paper: Sep 12,2024
q-bio.GN
ID:2409.07812
Highly conserved sequence-specific double-stranded DNA binding networks contributing to divergent genomic evolution of human and chimpanzee brain development
Emergence during mammalian evolution of concordant and divergent traits of
genomic regulatory networks encompassing ubiquitous, qualitatively nearly
identical yet quantitatively distinct arrays of sequences of transcription
factor binding sites (TFBS) for 716 proteins is reported. A vast majority of
TFs (770 of 716; 98%) comprising protein constituents of these networks appear
to share common Gene Ontology (GO) features of sequence-specific
double-stranded DNA binding (GO: 1990837). Genome-wide and individual
chromosome-level analyses of 17,935 ATAC-seq-defined brain development
regulatory regions (BDRRs) revealed nearly universal representations of TFBS
for TF-constituents of these networks, TFBS densities of which appear
consistently higher within thousands BDRRs of Modern Humans compare to
Chimpanzee. Transposable elements (TE), including LTR/HERV, SINE/Alu, SVA, and
LINE families, appear to harbor and spread genome-wide consensus regulatory
nodes of identified herein highly conserved sequence-specific double-stranded
DNA binding networks, selections of TFBS panels of which manifest individual
chromosome-specific profiles and species-specific divergence patterns.
Collectively, observations reported in this contribution highlight a previously
unrecognized essential function of human genomic DNA sequences encoded by TE in
providing genome-wide regulatory seed templates of highly conserved
sequence-specific double-stranded DNA binding networks likely contributing to
continuing divergent genomic evolution of human and chimpanzee brain
development.
🔗 View origin paper >>
Am I the publisher of this paper? I want to claim it
Claim
Paper Author: Gennadi Glinsky
Leave an answer
Hot post
Popular Paper